Identity & origin
BOTANICAL IDENTITY
The right name is the first step.
Perennial or subshrub in the Asteraceae family. Recorded native range: French Guiana to Ecuador. The listed pharmacopoeial material is leaf.
Also known as: No synonyms listed.
Check the species, plant part and complete botanical name together. A photograph alone cannot identify a harvest safely for consumption.
An illustration is not enough to identify a plant for consumption. Do not forage for a species based solely on this profile.
Uses & evidence
UNDERSTANDING THE USES
Properties & uses.
Pharmacopoeial material: leaf
The inventory also records the old names Eupatorium triplinerve and E. ayapana. The leaf is the material covered by this notice. This notice infers no therapeutic indication.
The references do not establish a benefit. Lack of evidence is not assurance of safety.
Read the sourceInflammation and permeability: a cell model
Glucose-induced inflammatory and permeability changes were attenuated. In-vitro model: neither stroke prevention nor diabetes management was demonstrated in humans.
Laboratory or animal observation. A human benefit cannot be inferred from this finding alone.
Read the sourceThe traditional uses described are not clinical proof of effectiveness. Evidence for one preparation cannot automatically be applied to another.
Precautions before use
BEFORE ANY USE
Precautions & contraindications.
This guidance does not cover every individual situation. Missing information is not a guarantee of safety.
Contraindications & precautions
- Insufficient dataThis targeted audit does not provide a comprehensive contraindication review; this does not mean contraindications are absent.
Medicine interactions
- Insufficient dataThis dossier cannot establish compatibility with medication. A limited study does not replace an interaction review of the exact product.
Other retained warnings · review incomplete
These existing warnings remain relevant to consult. Their exhaustive reassessment is outside this targeted review.
Restrictions and precautions
- This botanical dossier does not establish medicinal-use safety. Anyone with a medical condition or taking medicine needs professional assessment of the specific product.
Medicine interactions
- Interactions have not been sufficiently assessed in the sources retained for this notice; an incomplete assessment guarantees no compatibility.
Pregnancy, breastfeeding and children
No medicinal use is offered during pregnancy or breastfeeding; this dossier cannot establish safety in these situations.
No paediatric preparation or dose is offered in this notice.
“Reported” does not prove causality; “possible” may reflect indirect evidence. “None reported” means none in the cited source, not that all combinations have been studied. Do not stop a prescribed treatment based on this profile.
Adverse effects
- This notice does not provide a complete adverse-effect assessment. Historical use alone cannot exclude toxicity.
Pregnancy & breastfeeding
No medicinal use is offered during pregnancy or breastfeeding; this dossier cannot establish safety in these situations.
Children & adolescents
No paediatric preparation or dose is offered in this notice.
If symptoms persist, worsen or are unusual, consult a healthcare professional. In an emergency, contact the emergency services.
Forms & how they are used
DOCUMENTED FORMS
One plant, several preparations.
Only forms documented in this profile’s sources are presented.
Studied preparation — documentary referencePart not explicit in the abstract reviewed; do not infer it from the inventory. · Route: not recommended for self-treatment
Characterised polyphenol extracts from several plants, including Ayapana triplinervis.
Please note: Research description only; no self-treatment dose, recipe or duration is offered.
Read the sourceAvailable evidence
EXPLORE THE EVIDENCE
The available evidence.
This reference concerns a defined preparation of Ayapana triplinervis (Vahl) R.M.King & H.Rob.. The result is experimental: a compound, an extract and a whole plant differ, as do a laboratory assay and a human benefit.
Inflammation and permeability: a cell model
The model studies a cell barrier under controlled conditions, not a whole organism.
Laboratory or animal observation. A human benefit cannot be inferred from this finding alone.
Read the referenceLimitations to keep in mind.
The model studies a cell barrier under controlled conditions, not a whole organism.
Studies, findings & limitations
THE RESEARCH
What the research shows.
A laboratory or animal result alone does not demonstrate a benefit in humans. Each result must be read alongside the preparation studied and its limitations.
Inflammation and permeability: a cell model — 2021
Laboratory or animal observation. A human benefit cannot be inferred from this finding alone.
- Type of research
- Mouse cerebral endothelial cells exposed to high glucose.
- Preparation concerned
- Characterised polyphenol extracts from several plants, including Ayapana triplinervis.
- Observed results
- Glucose-induced inflammatory and permeability changes were attenuated.
- Limitations to consider
- In-vitro model: neither stroke prevention nor diabetes management was demonstrated in humans.
What can we take from this?
In-vitro model: neither stroke prevention nor diabetes management was demonstrated in humans. Interactions, pregnancy and long-term use require separate assessment.
Documentary review dated 09/10/2026. The references remain available to check the context.
Sources & last review
CHECKING REFERENCES
Sources for this profile.
- ANSM — French Pharmacopoeia, List A, January 2026, p. 6Accessed on 09/10/2026
- Kew POWO — Ayapana triplinervis (Vahl) R.M.King & H.Rob.Accessed on 09/10/2026
- Taïlé J et al. (2021) — Hyperglycemic Condition Causes Pro-Inflammatory and Permeability Alterations Associated with Monocyte Recruitment and Deregulated NFκB/PPARγ Pathways on Cerebral Endothelial Cells: Evidence for Polyphenols Uptake and Protective EffectAccessed on 09/10/2026
Image: R K · CC BY 4.0. View the original image and its licence. Image resized and converted to WebP.